Current work of Institut Curie – Year 3 of iPC started

22 February, 2021

The third year of iPC project has started and in order to present the current work that each consortium partner is developing, we asked them to summarize the processes that are being done behind the project. This week we start with the Institut Curie where Olivier Delattre explains the current work that his department is developing within iPC:

“My group is investigating tumor heterogeneity of Ewing sarcoma, a bone tumor of children and young adult characterized by a chromosome translocation which induces the expression of the chimeric EWS-FLI1 oncogene. We are using single cell analyses to explore the heterogeneity of the tumor cells with a particular interest in the variable activity of EWS-FLI1 from one cell to the other. Single cell analyses also enable to investigate the tumor microenvironment. We are also exploring the oncogenic role of the loss-of-function of STAG2 the mutation of which is the most frequent secondary alteration in Ewing sarcoma.”